Anti-wrinkle cream Rapamycin is a possible alternative to the invasive rejuvenation techniques that women have to resort to age-related skin changes. The drug is at the research stage, but already a large number of women dream of experiencing its effect on themselves.
Rapamycin – what is it?
Considering Rapamycin – what kind of drug it is, we immediately note that initially it began to be used for a completely different purpose, and its rejuvenating qualities were discovered later in the course of a deeper study. Rapamycin was first discovered in the early 1970s as a compound secreted by the bacterium Streptomyces hygroscopicus, which lives in the soil on Easter Island (Rapa Nui Island). Then antifungal properties were revealed and the development of medicines based on this substance began.
The powerful immunosuppressive and antiproliferative properties of Rapamycin have been proven, which made it possible to register this drug and use it in organ transplantation to prevent rejection. The drug is mainly used for kidney transplantation due to low toxicity to the tissues of these organs. In addition, the role of drugs during stenting of blood vessels to prevent re-narrowing after surgery is great. Today, active research is underway to use the anti-wrinkle cream Rapamycin to slow down aging.
Rapamycin – composition
The drug Rapamycin (sirolimus) is a product of the metabolism of soil microorganisms; from the point of view of chemistry, it is a lactam nitrogen-containing macrolide. It is known that this compound is poorly soluble, which makes it difficult to prepare stable galenic compositions based on it. In addition, the preparation of pharmaceuticals from it is limited by the low and variable bioavailability of Rapamycin.
How does Rapamycin work?
Before starting to test Rapamycin cream on human skin, scientists conducted many experiments, revealing that this compound can influence the biochemical processes in cells and prolong the life of experimental baker’s yeast, fruit flies, roundworms, and mice. It was found that Rapamycin, by binding to the cytosolic protein immunophilin, inhibits the activity of another important regulatory mediator protein called TOR (“target of Rapamycin”).
This leads to the blockade of several specific pathways along which signaling occurs regarding cell growth and metabolite, affecting the rate of cell division and the rate of protein synthesis. When the rate of cell growth and division slows down, the aging process also slows down. Similar changes are observed with a significant reduction in caloric intake. In addition, slowing down the vital activity of cells helps to reduce the likelihood of the formation of malignant tumors, which in many cases are the causes of death in the mature age of organisms.
There was an assumption that the studied compound can act in a similar way in relation to the tissues of the human body. In this regard, American scientists conducted an experiment involving people, during which participants applied a cream containing rapamycin daily to the back of one hand for several months. A placebo drug was applied to the second for comparison. Biopsy and blood tests were performed to assess the changes in the skin tissues that the cream with the drug Rapamycin causes.
As a result of the experiment, it was found that the anti-wrinkle cream Rapamycin increases the content of collagen in the dermis and reduces the concentration of p16 protein, which is considered a key marker of skin aging and is involved in the control of the cell life cycle. It is visually noticeable that rapamycin causes skin rejuvenation, as there was a decrease in the number of wrinkles, an even tone, and a decrease in tissue sagging. It should be noted that the cream with sirolimus did not affect the body systemically, because this substance was not found in the bloodstream during the period of external use.
Rapamycin – benefits and harms
Scientists continue to study Rapamycin (sirolimus), conduct studies (with the participation of experimental animals) in order to determine the exact effect of the substance on the cardiovascular system, circulatory system, immunity, vision, metabolic processes, and so on. At the same time, both positive and serious negative effects are revealed, which is why at the moment experiments and clinical trials in humans are limited.
The beneficial effects found suggest that:
- rapamycin for the skin can prevent the development of cutaneous Kaposi’s sarcoma after a kidney transplant;
- the drug promotes remission of tumors in the lungs, kidneys, brain, skin with tuberous sclerosis;
- rapamycin prevents the development of autism, Alzheimer’s disease, Parkinson’s disease;
- the compound can inhibit the spread of HIV in the body.
Side effects that this remedy may cause:
- increased insulin resistance (increased risk of developing diabetes);
- deterioration in glucose tolerance;
- development of interstitial pneumonitis;
- the development of certain types of cancer due to suppression of the immune system;
- urinary tract infections;
- peripheral edema and so on.
Rapamycin – indications
While Rapamycin for rejuvenation is only planned for use subject to successful trials, medicines with its content are already prescribed to patients in such cases:
- prevention of transplant rejection at low or moderate immunological risk after kidney transplantation;
- prevention of re-narrowing in the area of eliminated stenosis during stenting of coronary arteries (in the form of implantable stents, on the surface of which an antiproliferative coating based on polymerized rapamycin is applied);
- treatment of lymphangioleiomyomatosis, a rare progressive lung disease that often affects women under 50 years of age (approved for the treatment of this disease in 2015).
Rapamycin – contraindications
Sirolimus tablets and solution cannot be administered after transplantation in such cases:
- increased individual sensitivity to the active substance;
- glucose-galactose malabsorption;
- deficiency of lactase or sucrase;
- lactose intolerance.
With extreme caution, the medicine is used for:
- the simultaneous use of drugs that affect the functioning of the kidneys;
- violations of the functions of the liver.
Rapamycin for wrinkles
Accidentally discovered by biologists, a drug that slows down skin aging (the drug turned out to be Rapamycin) can serve as the basis not only for the creation of anti-aging cosmetics, but also for the creation of a real anti-aging drug. To do this, a series of experiments are being carried out, including the possibility of combining this compound with the hypoglycemic drug metformin, which will prevent the onset of some undesirable effects.
Where is Rapamycin found?
The drug Rapamycin, which is produced by Streptomyces hygroscopicus bacteria, which lives mainly in the soil and in plant debris, is obtained in the laboratory. It is worth noting that on the basis of this bacterial culture, scientists have created a number of other useful compounds, including antibiotics, anti-cancer agents, antiparasitic and antifungal drugs.
Preparations containing Rapamycin
The drug Rapamun is one of the most famous drugs based on Rapamycin. In addition to it, there are also the following preparations with its content for internal use (tablets, injection solution):
- Starket and some others.
Rapamycin in products
Some patients have questions as to whether it is possible to use Rapamycin on their own, where it is contained, from what it can be “extracted”. As already mentioned, this compound is an element of the metabolism of a certain type of soil bacteria. To obtain the drug, these bacterial cultures are grown in laboratories under special conditions.
Can I buy Rapamycin?
Preparations containing Rapamycin can be purchased at a pharmacy without a doctor’s prescription. To save money, you can use the services of one of the services that offer the delivery of certified medicines from foreign countries, directly from pharmaceutical manufacturing plants. We are talking about the forms of preparations for internal use, because the anti-wrinkle cream Rapamycin is not yet available for patients.
How to make a cream with Rapamycin?
At the moment, the cream with Rapamycin is not for sale. It is not possible to make it at home, including due to the fact that there is no data on the concentration in which the active substance should be contained in the external agent. It is worth warning anyone who dreams of rejuvenating with the help of this compound from using it on its own, which is associated with a high risk of dangerous side effects.
Rapamycin – analogues
Sirolimus, Rapamun, Spiracin – all of these drugs listed above are analogues, or generics, with the inclusion of the same active ingredient. The main manufacturers of these drugs are the USA, India, Turkey, and Italy. It should be understood that these drugs should be taken only as directed by a doctor, strictly dosing and observing all related recommendations.